Title :
Model of a conductimetric urea sensor
Author :
Sheppard, Norman F., Jr. ; Mears, David J.
Author_Institution :
Dept of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA
Abstract :
A model for predicting the response of a conductimetric urea sensor was developed. The sensor under consideration is formed by immobilizing the enzyme urease onto the surface of a planar interdigitated electrode array. The analysis combines a mass transport model with an electromagnetic fields model for calculating interelectrode impedance. The transport model was used to determine the evolution of charged reaction products in time and space. Interelectrode impedance was calculated from the resulting ionic conductivity profiles using the fields model. The calibration curve resulting from the model predictions was in good agreement with experimental data, using a single adjustable parameter
Keywords :
biosensors; calibration; chemical sensors; electrochemical analysis; electrochemical electrodes; finite difference methods; interdigital transducers; ionic conductivity; modelling; proteins; biosensors; calibration curve; charged reaction products; conductimetric urea sensor; electromagnetic fields model; enzyme-based; finite difference model; interelectrode impedance; ionic conductivity profiles; mass transport model; model; model predictions; planar interdigitated electrode array; Biochemistry; Conductivity; Electrodes; Electromagnetic analysis; Electromagnetic fields; Electromagnetic modeling; Predictive models; Sensor arrays; Space charge; Surface impedance;
Conference_Titel :
Bioengineering Conference, 1993., Proceedings of the 1993 IEEE Nineteenth Annual Northeast
Conference_Location :
Newark, NJ
Print_ISBN :
0-7803-0925-1
DOI :
10.1109/NEBC.1993.404359
