Vascular autoregulation in a model using mechanosensory ion channels

Author

Craelius, William

Author_Institution

Dept. of Biomed. Eng., Rutgers Univ., Piscataway, NJ, USA

fYear

1993

fDate

18-19 Mar 1993

Firstpage

21

Lastpage

22

Abstract

Mechanosensory ion channels (MACs) are incorporated into a myogenic model, which states that blood flow is regulated, in part, through feedback regulation of vessel diameter, which is controlled by smooth muscles surrounding the afferent arterioles. Feedback to the smooth muscle effectors is provided by tension-dependent currents from MACs, consisting mainly of K⁺ efflux. Smooth muscles respond to depolarizing K⁺ currents by contraction. The model shows the ability of vascular beds to autoregulate flow in the presence of changing arterial pressures

Keywords

bioelectric phenomena; biomembrane transport; haemodynamics; mechanoception; physiological models; changing arterial pressures; depolarizing K⁺ currents; mechanosensory ion channels; myogenic model; smooth muscles; vascular autoregulation; vascular beds; vessel diameter feedback regulation; Biomedical engineering; Biomembranes; Blood flow; Blood pressure; Mathematical model; Mercury (metals); Muscles; State feedback; Steady-state; Uncertainty;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 1993., Proceedings of the 1993 IEEE Nineteenth Annual Northeast

Conference_Location

Newark, NJ

Print_ISBN

0-7803-0925-1

Type

conf

DOI

10.1109/NEBC.1993.404432

Filename

404432