Title :
Detection of glycated hemoglobin using 3-Aminophenylboronic acid modified graphene oxide
Author :
Siva Rama Krishna, V. ; Bhat, Navakanta ; Amrutur, Bharadwaj ; Chakrapani, K. ; Sampath, Smita
Author_Institution :
Dept. of Electr. Commun. Eng., Indian Inst. of Sci., Bangalore, India
Abstract :
This paper presents the chemical synthesis of 3-Aminophenylboronic acid (APBA) modified graphene oxide (GO) and its application to the electrochemical detection of glycated hemoglobin (GHb). The compound (GO-APBA) was synthesized by forming an amide linkage between the amino group (-NH2) of APBA and the carboxylic group (-COOH) of GO. The compound was characterized using IR spectroscopy. Detection of GHb was carried out using Electrochemical Impedance Spectroscopic (EIS) measurements with GO-APBA modified glassy carbon electrode as the working electrode.
Keywords :
biosensors; electrochemical impedance spectroscopy; electrochemical sensors; graphene; infrared spectra; proteins; 3-Aminophenylboronic acid; APBA modified graphene oxide; CxOy; IR spectroscopy; amide linkage; electrochemical detection; electrochemical impedance spectroscopy; glassy carbon electrode; glycated hemoglobin detection; Carbon; Chemicals; Compounds; Electrodes; Sensors; Spectroscopy; Sugar; 3-Aminophenylboronic acid; Electrochemical Impedance Spectroscopy; Glycated Hemoglobin; Graphene Oxide; IR Spectroscopy;
Conference_Titel :
Life Science Systems and Applications Workshop (LiSSA), 2011 IEEE/NIH
Conference_Location :
Bethesda, MD
Print_ISBN :
978-1-4577-0421-5
DOI :
10.1109/LISSA.2011.5754140
