Detection of glycated hemoglobin using 3-Aminophenylboronic acid modified graphene oxide

Author

Siva Rama Krishna, V. ; Bhat, Navakanta ; Amrutur, Bharadwaj ; Chakrapani, K. ; Sampath, Smita

Author_Institution

Dept. of Electr. Commun. Eng., Indian Inst. of Sci., Bangalore, India

fYear

2011

fDate

7-8 April 2011

Firstpage

1

Lastpage

4

Abstract

This paper presents the chemical synthesis of 3-Aminophenylboronic acid (APBA) modified graphene oxide (GO) and its application to the electrochemical detection of glycated hemoglobin (GHb). The compound (GO-APBA) was synthesized by forming an amide linkage between the amino group (-NH₂) of APBA and the carboxylic group (-COOH) of GO. The compound was characterized using IR spectroscopy. Detection of GHb was carried out using Electrochemical Impedance Spectroscopic (EIS) measurements with GO-APBA modified glassy carbon electrode as the working electrode.

Keywords

biosensors; electrochemical impedance spectroscopy; electrochemical sensors; graphene; infrared spectra; proteins; 3-Aminophenylboronic acid; APBA modified graphene oxide; C_xO_y; IR spectroscopy; amide linkage; electrochemical detection; electrochemical impedance spectroscopy; glassy carbon electrode; glycated hemoglobin detection; Carbon; Chemicals; Compounds; Electrodes; Sensors; Spectroscopy; Sugar; 3-Aminophenylboronic acid; Electrochemical Impedance Spectroscopy; Glycated Hemoglobin; Graphene Oxide; IR Spectroscopy;

fLanguage

English

Publisher

ieee

Conference_Titel

Life Science Systems and Applications Workshop (LiSSA), 2011 IEEE/NIH

Conference_Location

Bethesda, MD

Print_ISBN

978-1-4577-0421-5

Type

conf

DOI

10.1109/LISSA.2011.5754140

Filename

5754140