Title :
Shape effect of mesoporous silica nanoparticles on cellular and in vivo functions
Author :
Huang, Xinglu ; Chen, Xiaoyuan
Abstract :
The design of smart functional nanosystems for theranostics requires a thorough understanding of the interaction between nanoparticles (NPs) and biological systems. Recent observations suggest that physical parameters of NPs, like size, shape and surface charge, can dramatically affect the behaviors of NPs in biological systems and might, in part, determine the bioapplications of NPs. Among various factors, particle shape has been considered to play an important role in both cellular interactions with NPs and systemic distribution of NPs. However, limited information is available regarding the effects of particle shape on these biological behaviors.
Keywords :
biomedical materials; cellular biophysics; drug delivery systems; liver; mesoporous materials; nanomedicine; nanoparticles; patient diagnosis; polymers; silicon compounds; PEG modification; SiO2; aspect ratio; biliary excretion dysfunction; cell adhesion; cell migration; cell proliferation; cellular apoptosis; cellular functions; cytoskeleton formation; drug delivery systems; glomerular filtration dysfunction; hematology; histopathology; in vivo functions; in vivo nanoparticle biocompatibility; in vivo nanoparticle biodistribution; in vivo nanoparticle clearance; long rod MSN; mesoporous silica nanoparticle shape effects; mesoporous silica nanoparticles; nanoparticle bioapplications; nanoparticle size; nanoparticle surface charge; nanoparticle-biological system interaction; serum biochemistry; short rod MSN; smart functional nanosystem design; spleen; theranostics; Biological systems; In vivo; Mesoporous materials; Nanobioscience; Nanoparticles; Shape; Silicon compounds;
Conference_Titel :
Life Science Systems and Applications Workshop (LiSSA), 2011 IEEE/NIH
Conference_Location :
Bethesda, MD
Print_ISBN :
978-1-4577-0421-5
DOI :
10.1109/LISSA.2011.5754158
