Title :
Lable-free biosensor based on localized surface plasmon resonance in a multi-channel microfluidic chip
Author :
Huang, Chengjun ; Putzeys, Jan ; Ye, Jian ; Reekmans, Gunter ; Verhaegen, Katarina ; Lagae, Liesbet ; Verstreken, Kris ; Borghs, Gustaaf
Author_Institution :
Interuniversity Microelectron. Center (IMEC), Leuven
Abstract :
A label-free biosensor based on localized surface plasmon resonance (LSPR) was developed. A multi-channel microfluidic chip was integrated with the sensor, providing referencing channel to minimize noise level and improving the throughput. With a CCD as a detector, a sensitivity of 10-4 RIU was demonstrated. The adsorption of S-layer protein was detected successfully by the sensor system.
Keywords :
adsorption; bioMEMS; biosensors; gold; lab-on-a-chip; microfluidics; molecular biophysics; nanoparticles; proteins; surface plasmon resonance; Au; CCD detector; S-layer protein; adsorption; label-free biosensor; localized surface plasmon resonance; multichannel microfluidic chip; referencing channel; Biosensors; Charge coupled devices; Detectors; Microfluidics; Noise level; Plasmons; Proteins; Resonance; Sensor systems; Throughput; Biosensor; Gold nanoparticles; Localized surface plasmon resoance (LSPR); Microfluidic;
Conference_Titel :
Sensors Applications Symposium, 2009. SAS 2009. IEEE
Conference_Location :
New Orleans, LA
Print_ISBN :
978-1-4244-2786-4
Electronic_ISBN :
978-1-4244-2787-1
DOI :
10.1109/SAS.2009.4801774
