Lable-free biosensor based on localized surface plasmon resonance in a multi-channel microfluidic chip

Author

Huang, Chengjun ; Putzeys, Jan ; Ye, Jian ; Reekmans, Gunter ; Verhaegen, Katarina ; Lagae, Liesbet ; Verstreken, Kris ; Borghs, Gustaaf

Author_Institution

Interuniversity Microelectron. Center (IMEC), Leuven

fYear

2009

fDate

17-19 Feb. 2009

Firstpage

43

Lastpage

46

Abstract

A label-free biosensor based on localized surface plasmon resonance (LSPR) was developed. A multi-channel microfluidic chip was integrated with the sensor, providing referencing channel to minimize noise level and improving the throughput. With a CCD as a detector, a sensitivity of 10^-4 RIU was demonstrated. The adsorption of S-layer protein was detected successfully by the sensor system.

Keywords

adsorption; bioMEMS; biosensors; gold; lab-on-a-chip; microfluidics; molecular biophysics; nanoparticles; proteins; surface plasmon resonance; Au; CCD detector; S-layer protein; adsorption; label-free biosensor; localized surface plasmon resonance; multichannel microfluidic chip; referencing channel; Biosensors; Charge coupled devices; Detectors; Microfluidics; Noise level; Plasmons; Proteins; Resonance; Sensor systems; Throughput; Biosensor; Gold nanoparticles; Localized surface plasmon resoance (LSPR); Microfluidic;

fLanguage

English

Publisher

ieee

Conference_Titel

Sensors Applications Symposium, 2009. SAS 2009. IEEE

Conference_Location

New Orleans, LA

Print_ISBN

978-1-4244-2786-4

Electronic_ISBN

978-1-4244-2787-1

Type

conf

DOI

10.1109/SAS.2009.4801774

Filename

4801774