Nonlinear dynamical modeling of human hippocampal CA3-CA1 functional connectivity for memory prostheses

Author

Dong Song ; Hampson, Robert E. ; Robinson, Brian S. ; Opris, Ioan ; Marmarelis, Vasilis Z. ; Deadwyler, Sam A. ; Berger, Theodore W.

Author_Institution

Dept. of Biomed. Eng., Univ. of Southern California, Los Angeles, CA, USA

fYear

2015

fDate

22-24 April 2015

Firstpage

316

Lastpage

319

Abstract

This paper reports the first nonlinear dynamical model of human hippocampus for building memory prostheses. In this study, spike trains are recorded from the hippocampal CA3 and CA1 regions in epileptic patients performing two memory-dependent behavioral tasks. Using CA3 and CA1 spike trains as inputs and outputs respectively, second-order generalized Laguerre-Volterra models are built to capture the nonlinear dynamics underlying the spike train transformations. These models can predict the CA1 spike trains based on the CA3 spike train and thus be used as the computational basis of the hippocampal memory prosthesis.

Keywords

bioelectric phenomena; medical disorders; neurophysiology; prosthetics; CA1 spike trains; CA3 spike; epileptic patients; hippocampal memory prosthesis; human hippocampus CA3-CA1 functional connectivity; memory-dependent behavioral tasks; nonlinear dynamical model; second-order generalized Laguerre-Volterra models; spike train transformations; Computational modeling; Estimation; Kernel; MIMO; Neural engineering; Predictive models; Prosthetics;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Engineering (NER), 2015 7th International IEEE/EMBS Conference on

Conference_Location

Montpellier

Type

conf

DOI

10.1109/NER.2015.7146623

Filename

7146623