Design of a novel closed-loop deep brain stimulation system for Parkinson´s disease and obsessive-compulsive disorder

Author

Karamintziou, S.D. ; Piallat, B. ; Chabardes, S. ; Polosan, M. ; David, O. ; Tsirogiannis, G.L. ; Deligiannis, N.G. ; Stathis, P.G. ; Tagaris, G.A. ; Boviatsis, E.J. ; Sakas, D.E. ; Polychronaki, G.E. ; Nikita, K.S.

Author_Institution

Nat. Tech. Univ. of Athens, Athens, Greece

fYear

2015

fDate

22-24 April 2015

Firstpage

860

Lastpage

863

Abstract

We present a novel closed-loop subthalamic nucleus (STN) deep brain stimulation (DBS) scheme for Parkinson´s disease (PD) and obsessive-compulsive disorder (OCD). The algorithm is designed to effectuate real-time, adaptive stimulation employing the outcome of the 0-1 test for chaos as a state-specific biomarker. In case of a null outcome, the system identifies optimal patterns of stimulation desynchronizing pathologic neuronal activity with minimal energy consumption, on grounds of a stochastic dynamical model and an appropriately formulated cost function. Simulations are performed utilizing microelectrode recordings (MERs) acquired during 8 and 2 DBS surgical interventions for PD and OCD, respectively.

Keywords

biomedical electrodes; brain; closed loop systems; diseases; medical disorders; microelectrodes; neurophysiology; patient treatment; stochastic processes; Parkinson´s disease; closed-loop deep brain stimulation system; closed-loop subthalamic nucleus; microelectrode recordings; obsessive-compulsive disorder; stimulation desynchronizing pathologic neuronal activity; stochastic dynamical model; Brain stimulation; Chaos; Hospitals; Noise; Oscillators; Satellite broadcasting; Stochastic processes;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Engineering (NER), 2015 7th International IEEE/EMBS Conference on

Conference_Location

Montpellier

Type

conf

DOI

10.1109/NER.2015.7146759

Filename

7146759