Title :
The effects of drugs on Pluronic F127 structure
Author :
Sharma, P.K. ; Bhatia, S.R.
Author_Institution :
Dept. of Chem. Eng., Massachusetts Univ., Amherst, MA, USA
Abstract :
Small-angle neutron scattering was used to study the effects of several drugs and additives on the aggregation number, core and corona radii and interparticle interaction distance of Pluronic F127 micelles. Depending upon their molecular weight and partition coefficient, these drugs were found to cause changes in the micellar structure. Our findings have implications on the performance and design of F127 drug delivery formulations.
Keywords :
aggregation; colloids; drug delivery systems; drugs; molecular weight; neutron diffraction; polymer blends; F127 drug delivery formulations; Pluronic F127 micelles; Pluronic F127 structure; additive effects; aggregation number; core radius; corona radius; drug effects; interparticle interaction distance; micellar structure changes; molecular weight; partition coefficient; small-angle neutron scattering; Chemical engineering; Corona; Crystallization; Deuterium; Drug delivery; Light scattering; Liquids; Neutron spin echo; Storage area networks; Temperature control;
Conference_Titel :
Bioengineering Conference, 2004. Proceedings of the IEEE 30th Annual Northeast
Print_ISBN :
0-7803-8285-4
DOI :
10.1109/NEBC.2004.1300078
