Extracellular Optical Recording Configuration for Neuronal Action Potential Detection by using Surface Plasmon Resonance: Preliminary Experiment

Author

Baac, Hyoungwon ; Jun, Sang Beom ; Turner, James N. ; Shain, William ; Smith, Karen L. ; Shuler, Michael L. ; Kim, Sung June

Author_Institution

Nano-Bioelectron. & Syst. Res. Center, Seoul Nat. Univ.

fYear

2005

fDate

16-19 March 2005

Firstpage

332

Lastpage

335

Abstract

We propose an extracellular optical recording configuration for neuronal action potential detection by using surface plasmon resonance (SPR). The method does not use fluorescence dyes but still taking advantages of optical recording. As a preliminary experiment, the electrochemical SPR effect without neurons was investigated. This showed that a high resolution SPR setup (10^-4~10^~5 angular shift or more) is required to overcome noise and improve SPR signal. Several issues for neural signal recording are addressed to modify SPR optical configuration

Keywords

bio-optics; bioelectric potentials; cellular biophysics; electrochemistry; medical signal detection; neurophysiology; surface plasmon resonance; electrochemical surface plasmon resonance effect; extracellular optical recording configuration; neural signal recording; neuronal action potential detection; Dielectrics; Extracellular; Fluorescence; Microelectrodes; Neurons; Optical noise; Optical recording; Plasmons; Resonance; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Engineering, 2005. Conference Proceedings. 2nd International IEEE EMBS Conference on

Conference_Location

Arlington, VA

Print_ISBN

0-7803-8710-4

Type

conf

DOI

10.1109/CNE.2005.1419625

Filename

1419625