Title :
Extracellular Optical Recording Configuration for Neuronal Action Potential Detection by using Surface Plasmon Resonance: Preliminary Experiment
Author :
Baac, Hyoungwon ; Jun, Sang Beom ; Turner, James N. ; Shain, William ; Smith, Karen L. ; Shuler, Michael L. ; Kim, Sung June
Author_Institution :
Nano-Bioelectron. & Syst. Res. Center, Seoul Nat. Univ.
Abstract :
We propose an extracellular optical recording configuration for neuronal action potential detection by using surface plasmon resonance (SPR). The method does not use fluorescence dyes but still taking advantages of optical recording. As a preliminary experiment, the electrochemical SPR effect without neurons was investigated. This showed that a high resolution SPR setup (10-4~10~5 angular shift or more) is required to overcome noise and improve SPR signal. Several issues for neural signal recording are addressed to modify SPR optical configuration
Keywords :
bio-optics; bioelectric potentials; cellular biophysics; electrochemistry; medical signal detection; neurophysiology; surface plasmon resonance; electrochemical surface plasmon resonance effect; extracellular optical recording configuration; neural signal recording; neuronal action potential detection; Dielectrics; Extracellular; Fluorescence; Microelectrodes; Neurons; Optical noise; Optical recording; Plasmons; Resonance; Voltage;
Conference_Titel :
Neural Engineering, 2005. Conference Proceedings. 2nd International IEEE EMBS Conference on
Conference_Location :
Arlington, VA
Print_ISBN :
0-7803-8710-4
DOI :
10.1109/CNE.2005.1419625
