An Analog VLSI Stimulation and Recording System for Extracelluar Interfacing

This paper presents an analog VLSI system for extracellular interfacing to in vitro neural cultures on multielectrode arrays (MEAs). The design offers significant advantages: scalability to large numbers of electrodes, experimental flexibility in stimulation patterns, and suppression of stimulus artifacts. The paper includes experimental data demonstrating the performance of the recording system. Through the use of artifact suppression circuitry, the system reduces the duration of stimulus artifacts to < 2 ms. This reduction is effective for the stimulation electrode as well as neighboring electrodes