Title :
32-Channel Full Customized CMOS Biosensor Chip for Extracellular Neural Signal Recording
Author :
Zhang, Xin ; Daly, James C. ; Cao, Yong
Author_Institution :
Dept. of Electr. & Comput. Eng., Rhode Island Univ., Kingston, RI
Abstract :
In this paper we present a full-customized CMOS biosensor integrated circuit (IC) design, layout, and implementation techniques for extracellular multichannel action potential recording applications. Schematics and simulation data for each of the sub-circuit macros are presented which includes contact sensors, unity gain buffer, variable gain amplifier and logic control unit. The chip provides a satisfactory signal-to-noise ratio for neural signals with amplitudes in the range of 50-500 muV and frequency spectrum in the range of 20-2000 Hz. The prototype IC was fabricated by MOSIS using AMI´S 1.5 mum, double poly, double level metal CMOS technology
Keywords :
CMOS integrated circuits; bioelectric potentials; biomedical electrodes; cellular biophysics; integrated circuit layout; microelectrodes; neurophysiology; 20 to 2000 Hz; 50 to 500 muV; MOSIS; contact sensors; double level metal CMOS technology; extracellular multichannel action potential recording; extracellular neural signal recording; full customized CMOS biosensor; integrated circuit design; integrated circuit layout; logic control unit; neural signals; unity gain buffer; variable gain amplifier; Application specific integrated circuits; Biosensors; CMOS integrated circuits; CMOS logic circuits; CMOS technology; Circuit simulation; Extracellular; Gain; Integrated circuit layout; Signal to noise ratio;
Conference_Titel :
Neural Engineering, 2005. Conference Proceedings. 2nd International IEEE EMBS Conference on
Conference_Location :
Arlington, VA
Print_ISBN :
0-7803-8710-4
DOI :
10.1109/CNE.2005.1419711
