Title :
High-Throughput Endpoint and Real-Time Detection of Biochemical Reactions in Microarrays Using Label-Free Oblique-Incidence Reflectivity Difference Microscopes
Author :
Landry, J.P. ; Sun, Y.S. ; Lam, K.S. ; Zhu, X.D.
Author_Institution :
Univ. of California at Davis, Davis
Abstract :
We describe recently developed oblique-incidence reflectivity difference microscopes, a form of polarization-modulated imaging ellipsometry, for label-free detection of biochemical reactions in microarrays. Configurations enabling high-throughput endpoint and real-time detection on glass substrates are discussed.
Keywords :
biological techniques; ellipsometry; glass; glass substrates; high-throughput endpoint; label-free oblique-incidence reflectivity difference microscope; microarray biochemical reaction; polarization-modulated imaging ellipsometry; real-time detection; Biomedical optical imaging; Dielectric substrates; Fluorescence; Glass; Microscopy; Molecular biophysics; Optical reflection; Optical surface waves; Proteins; Reflectivity;
Conference_Titel :
Lasers and Electro-Optics, 2007. CLEO 2007. Conference on
Conference_Location :
Baltimore, MD
Print_ISBN :
978-1-55752-834-6
DOI :
10.1109/CLEO.2007.4453099
