Title :
Effects of nuisance parameters on the family-based linkage tests under general disease models
Author_Institution :
Div. of Molecular & Genomic Medicine, Nat. Health Res. Institutes, Taipei, Taiwan
Abstract :
Family-based linkage tests are methods for detection of the genetic basis of a disease. For the case-parent triad data, it is known that tests of linkage interfere with the association parameter under recessive disease models. The purpose of the paper is to discuss the effects of nuisance parameters on the family-based linkage tests under general models. It is shown that the linkage tests do not only interfere with the association parameter, but also with the gene substitution effect in general models.
Keywords :
biology computing; diseases; genetics; case-parent triad data; family-based linkage tests; gene substitution effect; general disease models; genetic disease basis; nuisance parameters; recessive disease models; Bioinformatics; Couplings; Diseases; Frequency; Genetics; Genomics; Humans; Medical tests; Prostate cancer; Testing;
Conference_Titel :
Parallel Architectures, Algorithms and Networks, 2004. Proceedings. 7th International Symposium on
Print_ISBN :
0-7695-2135-5
DOI :
10.1109/ISPAN.2004.1300546
