Nanodiamond as a multimodal platform for drug delivery and radiosensitization of tumor cells

Author

Petit, T. ; Girard, H.A. ; Combis-Schlumberger, M. ; Grall, R. ; Delic, J. ; Morel-Altmeyer, S. ; Bergonzo, P. ; Chevillard, S. ; Arnault, J.C.

Author_Institution

Diamond Sensors Lab., CEA, Gif-sur-Yvette, France

fYear

2013

fDate

5-8 Aug. 2013

Firstpage

174

Lastpage

178

Abstract

Nanodiamonds (NDs) are often considered as inert platforms with high interests for biomedical applications. They are well adapted for drug delivery, and may display embedded fluorescence. We report here on a new way to consider these nanocarbon particles, by revealing therapeutic capacities coming from electronic properties of NDs. With an optimized surface chemistry, the generation of Reactive Oxygen Species (ROS) occurs when those hydrogen-terminated NDs are exposed to photon irradiation, thus opening up the field towards the radiosensitization of tumor cells.

Keywords

biochemistry; cellular effects of radiation; diamond; drug delivery systems; fluorescence; nanomedicine; nanoparticles; radiation therapy; surface chemistry; tumours; C; ND electronic properties; ROS; Reactive Oxygen Species; biomedical applications; drug delivery; embedded fluorescence; hydrogen-terminated ND; inert platforms; multimodal platform; nanocarbon particles; nanodiamond; optimized surface chemistry; photon irradiation; therapeutic capacities; tumor cell radiosensitization; Chemicals; Diamonds; Materials; Nanobioscience; Plasmas; Surface treatment; Nanodiamonds; drug delivery; hydrogen; radiosensitization; zeta potential;

fLanguage

English

Publisher

ieee

Conference_Titel

Nanotechnology (IEEE-NANO), 2013 13th IEEE Conference on

Conference_Location

Beijing

ISSN

1944-9399

Print_ISBN

978-1-4799-0675-8

Type

conf

DOI

10.1109/NANO.2013.6720902

Filename

6720902