How does the saccadic eye movement controller adapt for pathological states?

Normal saccadic eye movements are time optimal. When a subject becomes fatigued he changes his control strategy and the eye movements are no longer time optimal. The cerebellum is the adaptive gain controller for the saccadic system. Patients with cerebellar disease have saccadic oscillations. Multiple sclerosis, lesions, and myasthenia gravis attenuate the transmission of the saccadic controller signals. This produces abnormal eye movements. The CNS compensates for this deficit by increasing the duration of the high-frequency motoneuronal saccadic pulse.