High-throughput biology in the time domain: Improving temporal resolution of single-molecule sensors

The rise of single-molecule sensors is leading to important changes in the design of high-throughput biotechnology platforms, as they migrate from slow but high-accuracy methods to faster and noisier techniques. These developments place new demands on electronic instrumentation to keep up with the fast asynchronous signals produced by these systems. We will review some of the recent developments in this area, and present examples from our work developing new electronic single-molecule sensing platforms.