Title :
A fast FPW-based protein concentration measurement system
Author :
Wang, Chua-Chin ; Hsu, Chia-Hao ; Tsai, Yue-Da ; Chen, Yun-Chi ; Lee, Ming-Chih ; Huang, I-Yu
Author_Institution :
Dept. of Electr. Eng., Nat. Sun Yat-Sen Univ., Kaohsiung, Taiwan
Abstract :
A fast protein concentration measurement system with two-port FPW (flexural plate wave) biosensors using a frequency-shift readout technique is presented in this paper. The proposed frequency-shift readout method employs a peak detecting scheme to measure the amount of resonant frequency shift. The frequency sweep range of the linear frequency generator is limited in 2 MHz to 10 MHz according to the characteristics of the FPW biosensors. The proposed frequency-shift readout circuit is verified on silicon using a standard 0.18 μm CMOS technology. The power consumption of the proposed protein concentration measurement system is 48 mW given a 0.1 MHz system clock. The protein concentration measurement is read out in less than 10 minutes.
Keywords :
CMOS integrated circuits; biomedical measurement; biosensors; chemical sensors; chemical variables measurement; elastic waves; molecular biophysics; proteins; CMOS technology; FPW based protein concentration measurement system; fast protein concentration measurement system; flexural plate wave biosensors; frequency 0.1 MHz; frequency 2 MHz to 10 MHz; frequency shift readout technique; frequency sweep range; linear frequency generator; peak detecting scheme; power 48 mW; resonant frequency shift; size 0.18 mum; two port FPW biosensors; Biosensors; Detectors; Frequency measurement; Immune system; Oscillators; Proteins; Resonant frequency; FPW; IgE antigen; frequency-shift readout circuit; peak detection; resonant frequency;
Conference_Titel :
Circuits and Systems (ISCAS), 2012 IEEE International Symposium on
Conference_Location :
Seoul
Print_ISBN :
978-1-4673-0218-0
DOI :
10.1109/ISCAS.2012.6271778
