Improvised NanoSPR biosensor system utilizing gold nanorods and nanohole array film

A compact and sensitive biosensor device is proposed to detect the biomolecular interactions and bindings. This device arrangement utilizes natural white light to excite the Surface Plasmon Resonance (SPR) property of the gold nanorods which are utilized as the interface for the detection of molecular interactions. Gold nanohole array film with multiple periodicities is used to filter the response of the gold nanorods at different wavelengths which increases the sensitivity of the device by several folds. A high signal-to-noise ratio (SNR) CMOS image sensors (CIS) are used to detect the filtered output response. A comparative analysis of two different photodiodes namely pinned (pinn) and n well-p substrate (nwell-psub) photodiodes were used to compare the performance of the proposed nanoSPR system. System level simulation shows that the pinned photodiode had better performance compare to the nwell-psub photodiode.