Contrast resonance imaging with microbubble resonance enhancement and suppression

A new set of multiple-pulse contrast modalities with combinations of power modulation (PM), pulse inversion (PI) and contrast resonance (CR) are proposed in order for contrast imaging sensitivity improvement. For the CR mode, an imaging pulse is ldquoembeddedrdquo in a long ldquoresonancerdquo pulse so that the dynamic ldquoresonantrdquo state of a contrast bubble encountered by the embedded imaging pulse is very different from the static state of the bubble for the imaging pulse alone. Numerical and experimental evaluations of the mode combinations indicate great potential for contrast imaging sensitivity improvement (without resolution degradation) over the standard PM or PI&PM mode.