Spectroscopic imaging of nano-particle distribution in biological tissue using optically assisted ultrasonic velocity-change detection

Author

Kawakami, S. ; Nakamura, N. ; Mukaiyama, T. ; Ishibasi, S. ; Wada, K. ; Matsuyama, T. ; Matsunaka, T. ; Kono, K. ; Horinaka, H.

Author_Institution

Dept. of Eng., Osaka Prefecture Univ., Sakai

fYear

2008

fDate

2-5 Nov. 2008

Firstpage

1302

Lastpage

1305

Abstract

The optically assisted ultrasonic velocity-change imaging method was applied to obtain the spectroscopic image of nano-particles, which were expected as markers for drug delivery system and photo-thermal therapy, in tissue mimic phantoms. Phantoms including gold nano-rods or semiconductor nano-particles were prepared. The ultrasonic velocity-change images of phantoms were obtained using illumination of laser diodes with various emission wavelengths corresponded to the absorption spectrum of nano-particle. Experimental results showed that our method has the potential to find the optical absorption agent in biological tissue.

Keywords

biological tissues; biomedical measurement; biomedical optical imaging; biomedical ultrasonics; gold; laser applications in medicine; nanoparticles; phantoms; photoacoustic effect; ultrasonic velocity; Au; absorption spectrum; biological tissue; drug delivery system; gold nanorod; laser diode illumination; nanoparticle distribution; optical absorption agent; optically assisted ultrasonic velocity-change detection; photo-thermal therapy; semiconductor nanoparticle; spectroscopic imaging; tissue mimic phantom; ultrasonic velocity-change image; Absorption; Biological tissues; Biomedical optical imaging; Drug delivery; Imaging phantoms; Medical treatment; Nanobioscience; Optical imaging; Spectroscopy; Ultrasonic imaging; component; gold nanorod; noninvasive imaging; spectroscopic; ultrasonic; velocity change;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium, 2008. IUS 2008. IEEE

Conference_Location

Beijing

Print_ISBN

978-1-4244-2428-3

Electronic_ISBN

978-1-4244-2480-1

Type

conf

DOI

10.1109/ULTSYM.2008.0315

Filename

4803389