Title :
Histotripsy for the treatment of BPH: evaluation in a chronic canine model
Author :
Hall, Timothy L. ; Hempel, Chris R. ; Lake, Alison M. ; Kieran, Kathy ; Ives, Kim ; Fowlkes, J. Brian ; Cain, Charles A. ; Roberts, William W.
Author_Institution :
Depts. of Urology, Univ. of Michigan, Ann Arbor, MI
Abstract :
Histotripsy was evaluated as a non-invasive BPH treatment. The prostates of 20 canine subjects were targeted with one of three histotripsy doses. Prostates were harvested immediately, 7 days, or 28 days after treatment and assessed for changes. Lower treatment doses were found to produced scattered cellular disruption and hemorrhage that was sometimes reversible. Higher doses perforated the urethra and produced cavities in the glandular prostate that healed to leave an enlarged urinary channel.
Keywords :
biological effects of acoustic radiation; biological organs; biological tissues; diseases; medical disorders; ultrasonic therapy; BPH treatment; benign prostate hyperplasia; chronic canine model; enlarged urinary channel; glandular prostate tissue; hemorrhage; histotripsy treatment dose; scattered cellular disruption; ultrasound therapy; urethra perforation; Abdomen; Acoustic scattering; Bladder; Focusing; Hemorrhaging; Lakes; Medical treatment; Probes; Transducers; Ultrasonic imaging;
Conference_Titel :
Ultrasonics Symposium, 2008. IUS 2008. IEEE
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2428-3
Electronic_ISBN :
978-1-4244-2480-1
DOI :
10.1109/ULTSYM.2008.0183
