Contrast-enhanced high-frequency ultrasound imaging of liver metastases in preclinical models

Author

Rui Chen ; Tomita, N. ; Baba, Taisuke ; Oosawa, F. ; Watanabe, Yoshihiro ; Horie, Shota ; Mori, Shiro ; Fukumoto, Manabu ; Kodama, Tetsuya

Author_Institution

Dept. of Biomed. Eng., Tohoku Univ., Tohoku

fYear

2008

fDate

2-5 Nov. 2008

Firstpage

1742

Lastpage

1744

Abstract

Preclinical mouse models are essential to the study of liver metastasis, yet their utility has been limited by difficulty in tracking the progression of metastases through time. In this study, liver metastases were identified by in vivo bioluminescence system and a high-frequency ultrasound system with nanobubbles. Tumor grows and vessel densities were calculated. Liver metastases were observed on the second days after inoculation and confirmed by the HE staining. Vessels density in the liver metastasis group was increased compared to the control group. This study show that three-dimensional high-frequency ultrasound imaging combined with nanobubbles may be suited for early detection, quantitative assessment of metastatic progression in liver metastasis models.

Keywords

bioacoustics; bioluminescence; biomedical ultrasonics; cancer; liver; patient diagnosis; tumours; HE staining; contrast-enhanced high-frequency ultrasound imaging; in vivo bioluminescence system; liver metastasis; nanobubbles; preclinical mouse model; tumor; vessel density; Acoustic imaging; Bioluminescence; Cancer; In vivo; Liver; Magnetic resonance imaging; Metastasis; Mice; Optical imaging; Ultrasonic imaging; high-frequency ultrasound; in vivo bioluminescence system; liver metastasis;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium, 2008. IUS 2008. IEEE

Conference_Location

Beijing

Print_ISBN

978-1-4244-2428-3

Electronic_ISBN

978-1-4244-2480-1

Type

conf

DOI

10.1109/ULTSYM.2008.0427

Filename

4803505