Title :
Overlapping/touching cell nuclei segmentation based on analysis of perpendicular distance curve
Author :
Mao, K.Z. ; Zhao, Pinghua ; Koh, T.S. ; Tan, P.H.
Author_Institution :
Sch. of Electr. & Electron. Eng., Nanyang Technol. Univ., Singapore, Singapore
Abstract :
In the present study, a concave points-based segmentation algorithm is developed for overlapping or touching cell nuclei. The main character of the algorithm is that it detects concave points through analyzing perpendicular distance from nuclei contour points to the medial axis of the nuclei. Experiment results show that the algorithm can segment complicated nuclei clumps.
Keywords :
biological techniques; cellular biophysics; image segmentation; medical image processing; concave points; concave points-based segmentation algorithm; medial axis; nuclei contour points; overlapping cell nuclei segmentation; perpendicular distance curve; touching cell nuclei segmentation; Algorithm design and analysis; Arteries; Biomedical image processing; Biomedical imaging; Hospitals; Image segmentation; Joints; Pathology; Pixel; Skeleton;
Conference_Titel :
Biomedical Engineering, 2003. IEEE EMBS Asian-Pacific Conference on
Print_ISBN :
0-7803-7943-8
DOI :
10.1109/APBME.2003.1302659
