• DocumentCode
    3041885
  • Title

    Feature Extraction of Colon Cancer´s Gene

  • Author

    Liu, Guangya ; Duan, Bin

  • Author_Institution
    Coll. of Electr. & Electron. Eng., Hubei Univ. of Technol., Wuhan, China
  • fYear
    2011
  • fDate
    14-17 Dec. 2011
  • Firstpage
    287
  • Lastpage
    290
  • Abstract
    In this paper, the gene features associated with colon cancer were extracted from the given colon cancer gene expression data by reasonable statistical methods and other mathematical methods. Firstly, the majority(80%-90%), of unrelated genes of which the linear normalized distance was below 0.2 were removed using Bhattacharyya weighted distance, then the weight of the corresponding trait genes and the corresponding threshold value were derived using the linear kernel SVM training feature gene subset. We found the best combination of genes(2-60) and picked out the optimal combination of genes with the lowest error rate as the ultimate combination of genes(5-7). Finally, we tested the optimal combination of genes on the test set and the error rate was below 3%, indicating high precision.
  • Keywords
    mathematical analysis; medical computing; statistical analysis; support vector machines; Bhattacharyya weighted distance; colon cancer gene; error rate; feature extraction; gene expression data; linear kernel SVM training feature gene subset; linear normalized distance; mathematical methods; statistical methods; test set; Cancer; Colon; Gene expression; Support vector machines; Testing; Training; Bhattacharyya weighted distance; FFSM; SVM;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Intelligent Computation and Bio-Medical Instrumentation (ICBMI), 2011 International Conference on
  • Conference_Location
    Wuhan, Hubei
  • Print_ISBN
    978-1-4577-1152-7
  • Type

    conf

  • DOI
    10.1109/ICBMI.2011.12
  • Filename
    6131765