Title :
A MEMS Sensor for Continuous Monitoring of Glucose in Subcutaneous Tissue
Author :
Huang, X. ; Li, S. ; Schultz, J. ; Wang, Q. ; Lin, Q.
Author_Institution :
Mech. Eng. Dept., Columbia Univ., New York, NY
Abstract :
We present a MEMS sensor for continuous glucose monitoring for diabetes management. The device consists of a microcantilever, which is driven by remote magnetic field and situated in a microchamber separated from the sensing environment by a semi-permeable membrane. As glucose concentration varies, viscosity changes induced by glucose/copolymer binding in a poly(acrylamide-ran-3-acrylamidophenylboronic acid) (PAA-ran-PAAPBA) copolymer solution produce a measurable change in cantilever vibration. The device has been used to measure physiologically relevant glucose concentrations from 0 to 324 mg/dL. The response time of the sensor to glucose concentration changes was 3 minutes and can be further improved with optimized device designs.
Keywords :
bioMEMS; biological tissues; biomedical equipment; biomedical measurement; cantilevers; medical disorders; membranes; microsensors; patient monitoring; physiology; polymer blends; viscosity; MEMS sensor; cantilever vibration; copolymer binding; copolymer solution; diabetes management; glucose concentration measurement; glucose monitoring; microcantilever; microchamber separation; poly(acrylamide-ran-3-acrylamidophenylboronic acid); remote magnetic field; semipermeable membrane; subcutaneous tissue; time 3 min; Biomedical monitoring; Biomembranes; Diabetes; Magnetic field measurement; Magnetic sensors; Micromechanical devices; Remote monitoring; Sugar; Vibration measurement; Viscosity;
Conference_Titel :
Micro Electro Mechanical Systems, 2009. MEMS 2009. IEEE 22nd International Conference on
Conference_Location :
Sorrento
Print_ISBN :
978-1-4244-2977-6
Electronic_ISBN :
1084-6999
DOI :
10.1109/MEMSYS.2009.4805391
