DocumentCode :
3045039
Title :
Mechanical Characterization of Biomolecules in Liquid using Silicon Tweezers with Subnanonewton Resolution
Author :
Yamahata, C. ; Sarajlic, E. ; Jalabert, L. ; Kumemura, M. ; Collard, D. ; Fujita, H.
fYear :
2009
fDate :
25-29 Jan. 2009
Firstpage :
607
Lastpage :
610
Abstract :
Molecular biophysicists seek to understand how biological systems work through mechanical or electrical characterizations performed at the molecular scale. From this perspective, we have devised a silicon-based micromechanical tool for stress-strain measurements of molecular fibers and demonstrated micro manipulation and biomechanical characterization of DNA bundles in a liquid solution. By combining this instrument with a microscopic displacement measurement technique based on Fourier transform image processing, we could achieve a force resolution of 25 pN - a level which is within the single-molecule sensing range - and validate a novel approach for stress-strain measurements.
Keywords :
DNA; Fourier transform optics; bioMEMS; biomechanics; medical image processing; molecular biophysics; nanobiotechnology; radiation pressure; silicon; stress-strain relations; DNA bundles; Fourier transform image processing; Si; biomolecules; force resolution; liquid solution; mechanical characterizations; micromanipulation; micromechanical tool; microscopic displacement measurement; molecular fibers; silicon tweezers; stress-strain measurements; subnanoNewton resolution; Biological systems; DNA; Displacement measurement; Force measurement; Instruments; Micromechanical devices; Microscopy; Molecular biophysics; Silicon; Stress measurement;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Micro Electro Mechanical Systems, 2009. MEMS 2009. IEEE 22nd International Conference on
Conference_Location :
Sorrento
ISSN :
1084-6999
Print_ISBN :
978-1-4244-2977-6
Electronic_ISBN :
1084-6999
Type :
conf
DOI :
10.1109/MEMSYS.2009.4805455
Filename :
4805455
Link To Document :
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