Integrated optrode array for neural stimulating and recording

Author

Sanyuan Chen ; Weihua Pei ; Qiang Gui ; Hui Zhao ; Yuanfang Chen ; Hongda Chen

Author_Institution

State Key Lab. on Integrated Optoelectron., Inst. of Semicond., Beijing, China

fYear

2012

fDate

28-30 Nov. 2012

Firstpage

196

Lastpage

199

Abstract

We present the design, fabrication, simulation and characterization of a novel optrode array for light delivery and neural recording on animal optogenetic experiment in vivo. With the help of a MT connector, the optrode was arranged into 1×6 linear array and can be firmly and simply connected to optical source. The optrode was fabricated from a fiber. Fiber tip is tapered by wet etching. Au/Cr film is deposited,insulated by parylene and exposed at the tip by RIE to integrate electrical recording sites on one side of the fiber. The typical impedance at 1 KHz and output power of the optrode is 80KΩ and 13mw when evaluated in vitro. Acute animal implant experiment shows the optrode can work well in ChR2 transgenic mice.

Keywords

bioelectric phenomena; biomedical equipment; chromium; fibre optic sensors; gold; integrated optics; metallic thin films; optical arrays; optical design techniques; optical fibre couplers; optical fibre fabrication; optical films; optical polymers; prosthetics; sputter etching; Au-Cr; Au-Cr film; ChR2 transgenic mice; MT connector; RIE; animal implantation; animal optogenetics; fiber tip; frequency 1 kHz; integrate electrical recording; integrated optrode array; light delivery; neural recording; neural stimulation; optical source; parylene; power 13 mW; wet etching; Arrays; Optical device fabrication; Optical fiber devices; Optical fibers; Optical recording; Stimulated emission;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Circuits and Systems Conference (BioCAS), 2012 IEEE

Conference_Location

Hsinchu

Print_ISBN

978-1-4673-2291-1

Electronic_ISBN

978-1-4673-2292-8

Type

conf

DOI

10.1109/BioCAS.2012.6418463

Filename

6418463