Influence of SOD Mimics on Activities of Cultured Hepatoma Cell Line

Author

Shumao, Ding ; Wang Liming ; Zhanru, Liao ; Hongfei, Li

Author_Institution

Lab. of Environ. Sci. Coll. of Life Sci., Huazhong Normal Univ., Wuhan

fYear

2007

fDate

6-8 July 2007

Firstpage

61

Lastpage

64

Abstract

Based on the free radical theory, considerable effort has been made in biochemistry to develop SOD mimics as therapeutic agents to eliminate excessive free radicals. Among widely used mimics, the SOD mimics (also named as the model of SOD, MSOD) have been indicated promising results with the possible future applications as a new antitumor medicine in clinic. The present study showed that this SOD mimic can inhibit the proliferation of human hepatoma SSMC-7721 cells and significantly affect cell cycles. These preliminary findings may pave the way for its wider application.

Keywords

biochemistry; cellular biophysics; enzymes; free radicals; molecular biophysics; patient treatment; biochemistry; cell proliferation; cultured hepatoma cell line; free radical theory; human hepatoma SSMC-7721 cells; inhibition effect; superoxide dismutase mimics; Biochemistry; Biological materials; Bovine; Cancer; Cells (biology); Diseases; Drugs; Educational institutions; Humans; Organisms;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering, 2007. ICBBE 2007. The 1st International Conference on

Conference_Location

Wuhan

Print_ISBN

1-4244-1120-3

Type

conf

DOI

10.1109/ICBBE.2007.19

Filename

4272503