Study on Quality Control of Silybin Powder for Injection

Author

Yang Shu-Liang ; Yang Hong-yu ; Wang Shu-jing ; Yang Bo

Author_Institution

Sch. of Pharmaceuticial, Harbin Commerce Univ. Harbin, Harbin

fYear

2007

fDate

6-8 July 2007

Firstpage

1314

Lastpage

1316

Abstract

To identify different quality control of Silybin powder for injection, some indexes such as loss on drying, insoluble particle, ignition dregs, content determining were analyzed.The results indicated that regression curve of Silybin powder for injection was Y = 47741X + 531.19, r = 0.999 9. Precision: average peak area was 11182.42, RSD was 0.4796% (n = 6) ; Stability: RSD was 1.030 9%, which indicated its good stability in 14 hours. The average recovery rate was 99.84%, RSD was 0.5935%. Sample content determination: Content of all samples was as much as 95%-105% of claimed values. The average sample content was 40.7499 mg/bottle. All indexes fit in with pharmacopoeia, which indicate the quality of this Silybin powder for injection can be efficiently controlled.

Keywords

drugs; drying; powders; quality control; solubility; Silybin powder; drying; ignition dregs; injection; insoluble particle; pharmacopoeia; Business; Cells (biology); Ignition; Methanol; Powders; Protection; Quality control; Stability; Temperature; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering, 2007. ICBBE 2007. The 1st International Conference on

Conference_Location

Wuhan

Print_ISBN

1-4244-1120-3

Type

conf

DOI

10.1109/ICBBE.2007.339

Filename

4272823