An electrical model of the cell-electrode interface for high-density microelectrode arrays

Author

Joye, Neil ; Schmid, Alexandre ; Leblebici, Yusuf

Author_Institution

Microelectronic Systems Laboratroy, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland

fYear

2008

fDate

20-25 Aug. 2008

Firstpage

559

Lastpage

562

Abstract

A point-contact model is presented, and an area-contact model has been analytically derived in order to model the electrical characteristic of the cell-electrode interface of high-density neuron cultures. The area-contact model is presented as a model more suitable for subcellular multi-electrode resolution, which is a requisite for modeling and simulating the electrical behavior of novel high-density microelectrode arrays. Furthermore, when the electrode is aligned and centered with the cell, an optimum electrode diameter for recording the electrical activity of neural cells can be analytically derived, which is between 7–8 μm with a typical load capacitance of 10 pF.

Keywords

Biomembranes; Capacitance; Cells (biology); Conductivity; Electric variables; Electrodes; Equivalent circuits; Microelectrodes; Neurons; Spatial resolution; Action Potentials; Animals; Computer Simulation; Computer-Aided Design; Equipment Design; Equipment Failure Analysis; Humans; Membrane Potentials; Microelectrodes; Models, Neurological; Neurons; Reproducibility of Results; Sensitivity and Specificity; Surface Properties;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE

Conference_Location

Vancouver, BC

ISSN

1557-170X

Print_ISBN

978-1-4244-1814-5

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2008.4649214

Filename

4649214