Title :
The mass spectrometric analysis of drugs and metabolites in urine
Author :
Lee, M.R. ; Hwang, D.G. ; Chien, C.C. ; Hu, S.H.
Author_Institution :
Fourth Dept., Chung-Shan Inst. of Sci. & Technol., Lung-Tang, Taiwan
Abstract :
A mass spectrometric analysis of MA (methamphetamine) was performed. Quantities of MA were determined by the selected ion monitoring (SIM) and selected reaction monitoring (SRM) techniques. The limits of detection of MA standard solution and MA in urine are discussed. The limit of detection of MA is less than 1 ng. A urine sample can be analyzed directly without pretreatment procedures. The time required for each analysis is within two minutes. It is concluded that mass spectrometry utilizing SIM or SRM is a powerful method for the analysis of forensically important drugs and their metabolites in body fluids
Keywords :
biomedical measurement; mass spectroscopic chemical analysis; monitoring; organic compounds; detectable limits; drugs; forensic science; mass spectrometric analysis; metabolites; methamphetamine; selected ion monitoring; selected reaction monitoring; standard solution; urine; Chemical technology; Drugs; Electrons; Ionization; Mass spectroscopy; Monitoring; Pharmaceutical technology; Probes; Solids; Temperature;
Conference_Titel :
Security Technology, 1991. Proceedings. 25th Annual 1991 IEEE International Carnahan Conference on
Conference_Location :
Taipei
Print_ISBN :
0-7803-0120-X
DOI :
10.1109/CCST.1991.202221
