The mass spectrometric analysis of drugs and metabolites in urine

Author

Lee, M.R. ; Hwang, D.G. ; Chien, C.C. ; Hu, S.H.

Author_Institution

Fourth Dept., Chung-Shan Inst. of Sci. & Technol., Lung-Tang, Taiwan

fYear

1991

fDate

1-3 Oct 1991

Firstpage

246

Lastpage

252

Abstract

A mass spectrometric analysis of MA (methamphetamine) was performed. Quantities of MA were determined by the selected ion monitoring (SIM) and selected reaction monitoring (SRM) techniques. The limits of detection of MA standard solution and MA in urine are discussed. The limit of detection of MA is less than 1 ng. A urine sample can be analyzed directly without pretreatment procedures. The time required for each analysis is within two minutes. It is concluded that mass spectrometry utilizing SIM or SRM is a powerful method for the analysis of forensically important drugs and their metabolites in body fluids

Keywords

biomedical measurement; mass spectroscopic chemical analysis; monitoring; organic compounds; detectable limits; drugs; forensic science; mass spectrometric analysis; metabolites; methamphetamine; selected ion monitoring; selected reaction monitoring; standard solution; urine; Chemical technology; Drugs; Electrons; Ionization; Mass spectroscopy; Monitoring; Pharmaceutical technology; Probes; Solids; Temperature;

fLanguage

English

Publisher

ieee

Conference_Titel

Security Technology, 1991. Proceedings. 25th Annual 1991 IEEE International Carnahan Conference on

Conference_Location

Taipei

Print_ISBN

0-7803-0120-X

Type

conf

DOI

10.1109/CCST.1991.202221

Filename

202221