Title :
Peri-event cross-correlation over time for analysis of interactions in neuronal firing
Author :
Paiva, Antonio R C ; Park, Il ; Sanchez, Justin C. ; Principe, Jose C.
Author_Institution :
Computational NeuroEngineering Laboratory, Department of Electrical and Computer Engineering, University of Florida, Gainesville, 32611, USA
Abstract :
Several methods have been described in the literature to verify the presence of couplings between neurons in the brain. In this paper we introduce the peri-event cross-correlation over time (PECCOT) to describe the interaction among the two neurons as a function of the event onset. Instead of averaging over time, the PECCOT averages the cross-correlation over instances of the event. As a consequence, the PECCOT is able to characterize with high temporal resolution the interactions over time among neurons. To illustrate the method, the PECCOT is applied to a simulated dataset and for analysis of synchrony in recordings of a rat performing a go/no go behavioral lever press task. We verify the presence of synchrony before the lever press time and its suppression afterwards.
Keywords :
Analytical models; Biomedical computing; Biomedical measurements; Couplings; Data analysis; Frequency synchronization; Laboratories; Neural engineering; Neurons; Performance analysis; Action Potentials; Algorithms; Animals; Biomedical Engineering; Electrophysiological Phenomena; Male; Models, Neurological; Neurons; Rats; Rats, Sprague-Dawley;
Conference_Titel :
Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE
Conference_Location :
Vancouver, BC
Print_ISBN :
978-1-4244-1814-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2008.4649558
