• DocumentCode
    3069693
  • Title

    Dynamic model of micropipettes in piezo-assisted ICSI

  • Author

    Bahadur, Issam M. ; Mills, James K.

  • Author_Institution
    Dept. of Mech. & Ind. Eng., Univ. of Toronto, Toronto, ON, Canada
  • fYear
    2012
  • fDate
    1-4 July 2012
  • Firstpage
    191
  • Lastpage
    196
  • Abstract
    In this paper, the full nonlinear equations of motion of an immersed glass micropipette driven longitudinally by a piezoelectric actuator are derived, based on Kane´s method. The Morison equation is adopted to model the hydrodynamic forces in which the drag force is approximated with a viscous damping force. The model presented shows that the longitudinal vibration of a micropipette results in excitation of its out-of-plane, lateral eigenmodes. The nonlinear dynamic model is in good agreement with experimental observations in the literature. Furthermore, an immersed glass micropipette with imbedded mercury is also considered. Simulation results show that the lateral deflection of a micropipette tip increases by adding mercury. This result, however, is inconsistent with the experimental results. The discrepancy is possibly attributed to the assumption of zero relative motion between the mercury contained in the glass micropipette and the glass micropipette. Consequently, it is suggested that a more general nonlinear dynamic model should include the dynamic coupling effects of mercury due to its motion within the micropipette, as it vibrates longitudinally.
  • Keywords
    bioMEMS; biological fluid dynamics; biomechanics; biomedical equipment; cellular biophysics; drag; glass; hydrodynamics; mercury (metal); nonlinear dynamical systems; nonlinear equations; piezoelectric actuators; viscosity; Kane method; Morison equation; drag force; dynamic coupling effects; hydrodynamic forces; imbedded mercury; immersed glass micropipette; intracytoplasmic sperm injection; lateral deflection; lateral eigenmodes; micropipettes; nonlinear dynamic model; nonlinear equations of motion; piezo-assisted ICSI; piezoelectric actuator; viscous damping force; zero relative motion; Dynamics; Microinjection; Kane´s method; microdissection; microinjection; piezo-assisted ICSI;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Complex Medical Engineering (CME), 2012 ICME International Conference on
  • Conference_Location
    Kobe
  • Print_ISBN
    978-1-4673-1617-0
  • Type

    conf

  • DOI
    10.1109/ICCME.2012.6275659
  • Filename
    6275659