Changes in heart rate elicited by vagal activity: a model study

Author

Rudy, Yoram ; Dexter, Franklin ; Levy, Matthew N.

Author_Institution

Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH, USA

fYear

1989

fDate

19-22 Sep 1989

Firstpage

131

Lastpage

133

Abstract

The cellular mechanisms responsible for changes in sinus cycle length elicited by vagal stimulation were studied by means of a mathematical model. The model incorporated a stimulation-mediated depletion of the releasable pool of acetylcholine in the nerve endings, degradation of acetylcholine in the neuroeffector junction, and a model of the electrical activity of a pacemaker cell based on the kinetics of six membrane ionic channels. The results obtained explain the underlying mechanisms of experimentally observed phenomena such as the linear increase in sinus cycle length with frequency of vagal stimulation, the shape of the phase response curve, oscillations in sinus cycle length (sinus arrhythmia), and synchronization (entrainment) of the sinus node by constant-frequency vagal stimulation

Keywords

cardiology; physiological models; acetylcholine releasable pool; electrical activity model; mathematical model; membrane ionic channels; nerve endings; neuroeffector junction; pacemaker cell; phase response curve; sinus arrhythmia; sinus cycle length; vagal activity; Biomedical engineering; Biomembranes; Degradation; Frequency synchronization; Heart rate; Kinetic theory; Mathematical model; Nerve endings; Pacemakers; Partial response channels;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology 1989, Proceedings.

Conference_Location

Jerusalem

Print_ISBN

0-8186-2114-1

Type

conf

DOI

10.1109/CIC.1989.130501

Filename

130501