A Platform for Identifying MicroRNA Targeting Genes

Author

Weng, Chia-Wei ; Chiang, ChangChih ; Huang, Chien-Hung ; Ng, Ka-Lok

Author_Institution

Dept. of Bioinf., Asia Univ., Wufeng, Taiwan

fYear

2009

fDate

22-24 June 2009

Firstpage

386

Lastpage

387

Abstract

We investigate the possibility that microRNA could act as an oncogene or tumor suppressor gene. Experimentally verified microRNA targeted genes information are integrated with microRNA and mRNA expression data to study this hypothesis, in which the Pearson correlation coefficient is used to quantify these relations. Cancer related microRNA and genes information are retrieved by literature search. Two microRNA targets prediction tools, miRanda and RNAHybrid, are used to obtained the binding minimum free energy and 3psilaUTR binding position for the target. A web based interface is set up for data display, which can be accessed at http://ppi.bioinfo.asia.edu.tw/mirna_target.

Keywords

Internet; bioinformatics; cancer; data mining; genetics; macromolecules; medical computing; molecular biophysics; tumours; 3psilaUTR binding position; Pearson correlation coefficient; Web based interface; binding minimum free energy; bioinformatics; cancer related microRNA; mRNA expression profile; microRNA targeting gene identification; oncogene; tumor suppressor gene; Asia; Bioinformatics; Biomedical engineering; Cancer; Computer science; Data engineering; Humans; Neoplasms; Testing; Text mining; mRNA expression profile; microRNA; microRNA expression profile; oncogene; tumor suppressor gene;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and BioEngineering, 2009. BIBE '09. Ninth IEEE International Conference on

Conference_Location

Taichung

Print_ISBN

978-0-7695-3656-9

Type

conf

DOI

10.1109/BIBE.2009.78

Filename

5211240