Title :
Interaction Based Functional Clustering of Genomic Data
Author :
Krishna, Ritesh ; Li, Chang-Tsun ; Buchanan-Wollaston, Vicky
Author_Institution :
Dept. of Comput. Sci., Univ. of Warwick, Coventry, UK
Abstract :
We present the first report on Granger causality based detection of functional modules from temporal gene expression data. The approach uses temporal causal relationships shared between pair of genes to derive a connection matrix, which is further analyzed using graph-theoretic techniques. The approach is evaluated against a synthesized dataset and a real biological dataset obtained for Arabidopsis thaliana. We show the effectiveness of our approach by analyzing the results using the existing biological literature.
Keywords :
bioinformatics; genomics; graph theory; pattern clustering; Arabidopsis thaliana; Granger causality based detection; biological dataset; gene expression data; genomic data functional clustering; graph-theoretic technique; Bioinformatics; Biomedical engineering; Clustering methods; Computer science; Data analysis; Economic forecasting; Gene expression; Genomics; Reverse engineering; Stock markets; clustering; granger causality; time-series;
Conference_Titel :
Bioinformatics and BioEngineering, 2009. BIBE '09. Ninth IEEE International Conference on
Conference_Location :
Taichung
Print_ISBN :
978-0-7695-3656-9
DOI :
10.1109/BIBE.2009.28
