DocumentCode
307517
Title
Electro-mediated damages in the narrowest pore of the voltage-gated K channels on skeletal muscle membrane
Author
Chen, W. ; Lee, R.C.
Author_Institution
Dept. of Surgery, Chicago Univ., IL, USA
Volume
1
fYear
1995
fDate
20-25 Sep 1995
Firstpage
355
Abstract
In this report the authors are trying to locate the conformational changes in membrane proteins, the voltage-gated K channels of skeletal muscle membrane, during exposure to a high voltage electric shock. Studies of the effects on channel functions correlated to protein structural residues extra- and intra-cellular, as well as intramembrane imply that for the narrowest pore the selectivity filter may be the most sensitive to the applied high voltage electrical field
Keywords
bioelectric phenomena; biomembrane transport; molecular biophysics; molecular configurations; muscle; proteins; K; applied high voltage electrical field; channel functions; conformational changes location; extracellular; intracellular; intramembrane; narrowest pore; protein structural residues; selectivity filter; Biomembranes; Cells (biology); Clamps; Electric shock; Muscles; Plasmas; Proteins; Protocols; Surgery; Voltage;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference
Conference_Location
Montreal, Que.
Print_ISBN
0-7803-2475-7
Type
conf
DOI
10.1109/IEMBS.1995.575147
Filename
575147
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