Title :
On the simultaneous fitting for tracer delay and dispersion in cerebral blood flow studies using oxygen-15 water and PET
Author :
Toussaint, P.-J. ; Meyer, E.
Author_Institution :
Neurological Inst., McGill Univ., Montreal, Que., Canada
Abstract :
Simulations were used to evaluate the feasibility of simultaneous estimation of CBF, partition coefficient, tracer delay and dispersion in the one-compartment CBF model by curve fitting. The accuracy and precision of these estimates were investigated by means of sensitivity functions. Despite the considerable variability (up to 50%) in the Δt and τ estimates, estimates of CBF were within 5% of their true values
Keywords :
blood flow measurement; brain; curve fitting; positron emission tomography; H2O; PET; curve fitting; medical diagnostic imaging; nuclear medicine; partition coefficient; sensitivity functions; tracer delay; Blood flow; Brain modeling; Delay effects; Delay estimation; Equations; Least squares approximation; Parameter estimation; Performance evaluation; Positron emission tomography; Shape;
Conference_Titel :
Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference
Conference_Location :
Montreal, Que.
Print_ISBN :
0-7803-2475-7
DOI :
10.1109/IEMBS.1995.575230
