DocumentCode
3078149
Title
TRIAL MASTER, an expert system to control clinical drug trials
Author
Dassen, Willem R M ; Gorgels, Anton P M ; Mulleneers, Rob ; Wellens, Hein J J
Author_Institution
Dept. of Cardiology, Limburg Univ., Maastricht, Netherlands
fYear
1989
fDate
19-22 Sep 1989
Firstpage
361
Lastpage
364
Abstract
An expert system has been designed to facilitate the proper application of inclusion and exclusion criteria for clinical drug trials. For six trials, these criteria were represented in rules and stored in knowledge bases. In three cases, a separate knowledge base was added, containing knowledge on ECG (electrocardiographic) criteria. For a series of 100 patients, the cardiologist and the expert system disagreed with regard to three patients. In 24 cases the patient was classified for at least one trial; 73 patients did not meet the requirements for inclusion in any trial. As an example, the evaluation of a patient with unstable angina is presented
Keywords
expert systems; medical computing; ECG criteria; TRIAL MASTER; cardiologist; clinical drug trials control; exclusion criteria; knowledge base; medical expert system; unstable angina; Cardiology; Clinical trials; Control systems; Drugs; Electrocardiography; Expert systems; Knowledge representation; Logistics; Myocardium; Testing;
fLanguage
English
Publisher
ieee
Conference_Titel
Computers in Cardiology 1989, Proceedings.
Conference_Location
Jerusalem
Print_ISBN
0-8186-2114-1
Type
conf
DOI
10.1109/CIC.1989.130566
Filename
130566
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