Title :
Simultaneous registration and intensity normalization of SPECT perfusion images
Author :
Silveira, Margarida ; Aguiar, Pedro M Q
Author_Institution :
Institute for Systems and Robotics / IST, Portugal
Abstract :
The analysis of 3D SPECT brain images requires several pre-processing steps such as registration, intensity normalization and brain extraction. Usually, registration is performed before intensity normalization, which requires robust registration methods, such as those based on the maximization of the Mutual Information (MI), which are computationally complex. In this paper we propose using a computationally simple method to perform the simultaneous registration and intensity normalization of SPECT brain perfusion images. The approach, which extends to 3D data a method originally proposed in [1] for 2D photographic images, estimates in alternate steps the intensity normalization parameters and the registration parameters. Our experiments, with real SPECT images, show that the proposed registration method leads to results similar to those obtained by using more expensive algorithms such as those based on the MI criterion.
Keywords :
Biomedical imaging; Blood flow; Brain; Chromium; Dementia; Image registration; Iterative algorithms; Least squares methods; Mutual information; Robots; brain SPECT; intensity normalization; medical image registration; Algorithms; Artificial Intelligence; Brain; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Pattern Recognition, Automated; Reproducibility of Results; Sensitivity and Specificity; Tomography, Emission-Computed, Single-Photon;
Conference_Titel :
Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE
Conference_Location :
Vancouver, BC
Print_ISBN :
978-1-4244-1814-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2008.4650430