Computational study of an augmented minimal model for glycaemia control

In this paper we introduce a new model structure for the metabolic effects of intravenous insulin on blood glucose in man and derive its parameter values from the widely used model of Sorensen. The proposed model attempts to combine the advantages of the existing comprehensive and minimal models. Validation of the new model is done through deriving equivalent nonparametric nonlinear models in the form of Principal Dynamic Modes. We show that the new structure can represent the insulin - glucose dynamics of healthy subjects as well as Type 1 and Type 2 diabetics, with appropriate adjustment in its parameters.