A Dielectric Dispersion Analysis using microwave bio-microsensor for droplet of liposome suspension with target biomolecules

Author

Takada, Kazumasa ; Fujimoto, Takafumi ; Yamashita, Katsumi ; Noda, Masaki

Author_Institution

Grad. Sch. of Sci. & Technol., Kyoto Inst. of Technol., Matsugasaki, Japan

fYear

2013

fDate

5-6 June 2013

Firstpage

82

Lastpage

83

Abstract

This paper reports, firstly, that it was newly found by our specific Dielectric Dispersion Analysis (DDA) that plural type of bound water with different relaxation frequencies exist in a suspension of liposome of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). Secondly, we observe that the interaction between the liposome and a specific target biomolecule depends on the type of target molecules (protein of carbonic anhydrase from bovine (CAB) and/or cholesterol, respectively), leading to the change in dielectric relaxation at different relaxation frequency of bound water.

Keywords

biochemistry; bioelectric phenomena; biomembranes; biosensors; dielectric relaxation; drops; electrochemical sensors; enzymes; microsensors; microwave detectors; molecular biophysics; suspensions; 1,2-dipalmitoyl-sn-glycero-3-phosphocholine; DDA; DPPC; Dielectric Dispersion Analysis; bound water; bovine; carbonic anhydrase; cholesterol; dielectric relaxation; droplet; liposome interaction; liposome suspension; microwave biomicrosensor; plural type; protein; relaxation frequency; specific target biomolecule; Lead;

fLanguage

English

Publisher

ieee

Conference_Titel

Future of Electron Devices, Kansai (IMFEDK), 2013 IEEE International Meeting for

Conference_Location

Suita

Print_ISBN

978-1-4673-6106-4

Type

conf

DOI

10.1109/IMFEDK.2013.6602251

Filename

6602251