DocumentCode
3084853
Title
Nucleotide Fluctuation Analysis of Dim-Light Vision Rhodopsin Gene and mRNA Sequences in Vertebrates
Author
Holden, Todd ; Gadura, N. ; Cheung, E. ; Rada, J. ; Schneider, P. ; Tremberger, G., Jr. ; Sunil, D. ; Lieberman, D. ; Cheung, T.
Author_Institution
Phys. Dept., CUNY, Bayside, NY, USA
fYear
2010
fDate
18-20 June 2010
Firstpage
1
Lastpage
4
Abstract
Fractal dimension and Shannon entropy were used to analyze the nucleotide fluctuation of dim-light vision rhodopsin gene. The maximal absorption wavelengths of the studied gene sequences span a range of 480 nm to 526 nm. The di-nucleotide Shannon entropy correlates with (a) the mono-nucleotide Shannon entropy with R2 of 0.99; (b) the CG+GC content with R2 of 0.86 (N = 6). The absorption maximal wavelength correlation with the CG+GC content was found to have an R2 of 0.82 for the gene sequence and 0.91 for the mRNA sequence. The fractal dimensions of the gene sequences and mRNA sequences were found to be correlated with R2 of 0.78. Selection pressure on the CG+GC content at the gene and mRNA levels would be a consistent observation for phenotype dim-light functionality.
Keywords
biological techniques; biology computing; entropy; genetics; molecular biophysics; molecular configurations; CG+GC content; absorption maximal wavelength correlation; dim-light vision rhodopsin gene sequence; fractal dimension; mRNA levels; mRNA sequence; maximal absorption wavelengths; mononucleotide Shannon entropy; nucleotide fluctuation analysis; phenotype dim-light functionality; vertebrates; Absorption; Acceleration; Bioinformatics; Entropy; Fluctuations; Fractals; Genomics; Humans; Protons; Sequences;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on
Conference_Location
Chengdu
ISSN
2151-7614
Print_ISBN
978-1-4244-4712-1
Electronic_ISBN
2151-7614
Type
conf
DOI
10.1109/ICBBE.2010.5514714
Filename
5514714
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