Title :
Deducing Chemical Reaction Rate Constants and Their Regions of Confidence from Noisy Measurements of Time Series of Concentration
Author :
Lecca, Paola ; Palmisano, Alida ; Priami, Corrado
Author_Institution :
Centre for Comput. & Syst. Biol., Univ. of Trento, Povo
Abstract :
We present a new method for estimating rate coefficients from noisy observations of concentration levels at discrete time points. Our inference method is based on a new maximum likelihood approach to the estimation of probability density function of the variations in reactant concentration. The inference procedure returns the rate coefficients with their intervals of confidence, and the variance of noise in the input data.
Keywords :
chemical reactions; maximum likelihood estimation; time series; chemical reaction rate constants; discrete time points; inference method; maximum likelihood approach; noise variance; noisy measurements; probability density function; reactant concentration; time series; Chemicals; Time measurement; biochemical networks; parameter inference;
Conference_Titel :
Computer Modelling and Simulation, 2009. UKSIM '09. 11th International Conference on
Conference_Location :
Cambridge
Print_ISBN :
978-1-4244-3771-9
Electronic_ISBN :
978-0-7695-3593-7
DOI :
10.1109/UKSIM.2009.18
