Personalized neuromuscular blockade through control: Clinical and technical evaluation

Author

Silva, Margarida M. ; Mendonca, Teresa ; Esteves, Simão

Author_Institution

DMA, FCUP, Rua do Campo Alegre, 687, 4169-007 Porto, Portugal

fYear

2008

fDate

20-25 Aug. 2008

Firstpage

5826

Lastpage

5829

Abstract

This paper presents a statistical analysis of clinical data collected in surgeries under automatic closed-loop control of neuromuscular blockade. Four different control strategies have been applied in patients undergoing elective surgeries and clinical and technical evaluations of the control system were performed. Both transient and steady-state behaviour were analysed in detail and clearly suggest an automatic control approach relying on the information about the patient dynamics. The results can be a valuable start point to design personalized drug infusion control in anaesthesia.

Keywords

Automatic control; Control systems; Drugs; Information analysis; Neuromuscular; Performance evaluation; Statistical analysis; Steady-state; Surges; Transient analysis; Anaesthesia; Neuromuscular Blockade; On-line autocalibration; PID; Switching Control; Algorithms; Computer Simulation; Dose-Response Relationship, Drug; Drug Therapy, Computer-Assisted; Electroencephalography; Electromyography; Humans; Models, Biological; Neuromuscular Blockade; Neuromuscular Blocking Agents;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE

Conference_Location

Vancouver, BC

ISSN

1557-170X

Print_ISBN

978-1-4244-1814-5

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2008.4650539

Filename

4650539