Title :
Personalized neuromuscular blockade through control: Clinical and technical evaluation
Author :
Silva, Margarida M. ; Mendonca, Teresa ; Esteves, Simão
Author_Institution :
DMA, FCUP, Rua do Campo Alegre, 687, 4169-007 Porto, Portugal
Abstract :
This paper presents a statistical analysis of clinical data collected in surgeries under automatic closed-loop control of neuromuscular blockade. Four different control strategies have been applied in patients undergoing elective surgeries and clinical and technical evaluations of the control system were performed. Both transient and steady-state behaviour were analysed in detail and clearly suggest an automatic control approach relying on the information about the patient dynamics. The results can be a valuable start point to design personalized drug infusion control in anaesthesia.
Keywords :
Automatic control; Control systems; Drugs; Information analysis; Neuromuscular; Performance evaluation; Statistical analysis; Steady-state; Surges; Transient analysis; Anaesthesia; Neuromuscular Blockade; On-line autocalibration; PID; Switching Control; Algorithms; Computer Simulation; Dose-Response Relationship, Drug; Drug Therapy, Computer-Assisted; Electroencephalography; Electromyography; Humans; Models, Biological; Neuromuscular Blockade; Neuromuscular Blocking Agents;
Conference_Titel :
Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE
Conference_Location :
Vancouver, BC
Print_ISBN :
978-1-4244-1814-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2008.4650539
