Labs-on-a-chip and nanosensors for medical applications and life sciences

Two different types of nanosensors recently developed in our group are presented in this article. Silicon nanowire (Si-NW) field effect sensors have been developed and recent measurements demonstrating pH sensors with Nernstian sensitivity as well as real-time DNA hybridization measurements with binding affinity assessment are presented. Metal nanostructured surfaces are presented with periodically self-aligned nanopyramid and nanowire structures with precisely defined pitch and nanogap dimensions spanning large areas that form high-density arrays of hot-spot scattering sites ideally suited for surface-enhanced Raman scattering (SERS) and Raman spectroscopy.