A New Graphical Representation and Its Application in Similarity/Dissimilarity Analysis of DNA Sequences

The JZ-curve, a new graphical expression of the gene sequence, is introduced. This representation not only avoids the limitations associated with crossing and overlapping, but also retains the biological information of gene sequences. At the same time, we constructed a new characteristic matrix, named J/J matrix. Simultaneously, the J/J characteristic matrix based on JZ-curve can describe the chemical characteristic and the biological significance of gene sequences. The examination of similarities/dissimilarities among the coding sequences of the first exon of β-globin gene of different species illustrates the utility of the approach.