Observations of Pathomorphology and Antioxidative Function of Brain Tissue in Chickens with Aluminum Exposure

Author

Zhu Yan-zhu ; Li Yan-fei ; Gu Qing-Yun ; Liu Yun-Feng

Author_Institution

Coll. of Veterinary Med., Northeast Agric. Univ., Harbin, China

fYear

2010

fDate

18-20 June 2010

Firstpage

1

Lastpage

4

Abstract

The activities of superoxide dismutase (SOD) and concentrations of malondialdehyde (MAD) in cerebrum and cerebellum and pathomorphology of brain tissue were detected in chickens with different levels sub-chronic aluminum (Al) intoxication produced by continuous peritoneal injection of fixed volume and different gradient aluminum trichloride (AlCl3). The results showed that the activities of SOD in cerebrum and cerebellum were lower and the concentrations of MAD was higher in the experimental groups than in the control group (P<;0.05 or P<;0.01). There was dose-effect relationship between with AlCl3. Swell, atrophy, necrosis and karyopycnosis were observed in cerebrum centrum neurocytes and Purkinje´s cells of cerebellum by light microscope, which indicated that Al exposure damaged the brain tissue of chickens.

Keywords

aluminium compounds; biological tissues; brain; cellular biophysics; chemical hazards; diseases; neurophysiology; toxicology; AlCl₃; Purkinje´s cells; aluminum trichloride; antioxidative function; atrophy; brain tissue; cerebellum; cerebrum centrum neurocytes; dose-effect relationship; karyopycnosis; malondialdehyde; necrosis; pathomorphology; subchronic aluminum; superoxide dismutase; Aluminum; Animals; Atrophy; Biological materials; Brain; Educational institutions; Inorganic materials; Medical treatment; Microscopy; Nervous system;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on

Conference_Location

Chengdu

ISSN

2151-7614

Print_ISBN

978-1-4244-4712-1

Electronic_ISBN

2151-7614

Type

conf

DOI

10.1109/ICBBE.2010.5515231

Filename

5515231