Label free detection of human MIG using AlGaN/GaN high electron mobility transistor

The paper demonstrates a novel way of detecting Monokine induced by interferon gamma (MIG) in physiological condition (150mM phosphate buffer solution) using a two terminal device. To provide specific MIG detection capability, anti-MIG IgG molecular affinity interface receptors were formed on a short self-assembled monolayer (SAM) on a floating gold sensing gate of a biochemically modified AlGaN/GaN high electron mobility transistor (HEMT) device. Floating gate configuration used for biomolecule detection eliminates the need of external gate voltage and represents purely the effect of biomolecules immobilization and binding events on the gate surface.