Steeper Action Potential Duration Restitution Slope Increases Risk of Ventricular Fibrillation: A Simulation Study

Author

Zheng, Yi ; Wei, Daming ; Fang, Zuxiang

Author_Institution

Dept. of Electron. Eng., Fudan Univ., Shanghai, China

fYear

2010

fDate

18-20 June 2010

Firstpage

1

Lastpage

4

Abstract

Action potential duration restitution (APDR) is thought to be relevant to the stability of cardiac electrophysiology. Ventricular fibrillation (VF) was simulated using the Wei-Harumi model by taking into account piecewise linear action potential duration restitution based on clinical findings. We found, in the simulation, that heart model with steeper slope of APDR required less ectopic stimuli to trigger VF. This result suggested that the APDR may affect cardiac vulnerability to VF.

Keywords

bioelectric phenomena; cardiovascular system; diseases; medical computing; APDR; Wei-Harumi model; action potential duration restitution slope; cardiac electrophysiology; cardiac vulnerability; ectopic stimuli; heart model; piecewise linear action potential duration restitution; simulation study; ventricular fibrillation; Cancer; Cardiovascular diseases; Computational modeling; Computer science; Computer simulation; Fibrillation; Heart rate variability; Industrial accidents; Piecewise linear techniques; Stability;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on

Conference_Location

Chengdu

ISSN

2151-7614

Print_ISBN

978-1-4244-4712-1

Electronic_ISBN

2151-7614

Type

conf

DOI

10.1109/ICBBE.2010.5515680

Filename

5515680